Over the past two decades, developmental biologists have made great strides in understanding embryonic pattern formation at the genetic, molecular, and cellular levels. Much of this advancement can be attributed to the remarkable success of studies of pattern formation in model systems, such as the fruit fly Drosophila melanogaster. Identification of genes that play major roles in setting up the body plan, combined with the subsequent discovery that many of these genes are well conserved even between different phyla, has also led to a renaissance in the investigation of the links between evolution and development. Using information collected from studies of Drosophila development, my lab and others are beginning to explore the degree to which developmental pathways have been conserved or altered between various arthropods. Insights into the nature of developmental and molecular alterations will help us to understand the evolutionary changes in the mechanisms of pattern formation and provide a molecular basis for analyzing the diversification of body morphologies and developmental mechanisms.
A meta-analysis of butterfly structural colors: their color range, distribution and biological production.
A meta-analysis of butterfly structural colors: their color range, distribution and biological production. J Exp Biol. 2023 11 01; 226(21).
PMID: 37937662
Discovery of the bicycle gene family provides new insights into insect manipulation of plant development during gall induction.
Discovery of the bicycle gene family provides new insights into insect manipulation of plant development during gall induction. Fac Rev. 2023; 12:16.
PMID: 37449009
Dual Functions of labial Resolve the Hox Logic of Chelicerate Head Segments.
Dual Functions of labial Resolve the Hox Logic of Chelicerate Head Segments. Mol Biol Evol. 2023 03 04; 40(3).
PMID: 36798978
The BET inhibitor/degrader ARV-825 prolongs the growth arrest response to Fulvestrant + Palbociclib and suppresses proliferative recovery in ER-positive breast cancer.
The BET inhibitor/degrader ARV-825 prolongs the growth arrest response to Fulvestrant + Palbociclib and suppresses proliferative recovery in ER-positive breast cancer. Front Oncol. 2022; 12:966441.
PMID: 36741704
The Daphnia carapace and other novel structures evolved via the cryptic persistence of serial homologs.
The Daphnia carapace and other novel structures evolved via the cryptic persistence of serial homologs. Curr Biol. 2022 09 12; 32(17):3792-3799.e3.
PMID: 35858617
Expression of Abdominal-B in the brine shrimp, Artemia franciscana, expands our evolutionary understanding of the crustacean abdomen.
Expression of Abdominal-B in the brine shrimp, Artemia franciscana, expands our evolutionary understanding of the crustacean abdomen. Dev Biol. 2022 09; 489:178-184.
PMID: 35732224
Identification and classification of cis-regulatory elements in the amphipod crustacean Parhyale hawaiensis.
Identification and classification of cis-regulatory elements in the amphipod crustacean Parhyale hawaiensis. Development. 2022 06 01; 149(11).
PMID: 35608283
The crustacean model Parhyale hawaiensis.
The crustacean model Parhyale hawaiensis. Curr Top Dev Biol. 2022; 147:199-230.
PMID: 35337450
Mimicry can drive convergence in structural and light transmission features of transparent wings in Lepidoptera.
Mimicry can drive convergence in structural and light transmission features of transparent wings in Lepidoptera. Elife. 2021 12 21; 10.
PMID: 34930525
Developmental, cellular and biochemical basis of transparency in clearwing butterflies.
Developmental, cellular and biochemical basis of transparency in clearwing butterflies. J Exp Biol. 2021 05 15; 224(10).
PMID: 34047337